- Since last week, President Donald Trump has lauded chloroquine and hydroxychloroquine as potential treatment options for COVID-19.
- While there is some evidence that supports their effectiveness against the virus, health officials warn that not enough testing has been done to approve their widespread use.
- Still, people have begun trying to acquire the potential antiviral, leading to shortages for people who need it for it’s already approved treatments for lupus and rheumatoid arthritis.
Shortages of Hydroxychloroquine for People Who Need It
While panic buying has to lead to toilet paper and cleaning supplies shortages across the nation, it’s now also making it harder for some people to get their hands on medicine they’ve taken for years.
An influx of worried Americans are rushing to get ahold of hydroxychloroquine, a drug that treats diseases and disorders such as malaria, rheumatoid arthritis, and lupus. It’s also been hailed by President Donald Trump as an effective drug against COVID-19.
But that’s still unknown.
While there is evidence to support hydroxychloroquine or the similarly-touted chloroquine’s effectiveness against the pandemic, there is currently still not enough evidence to prove it should be used as a widespread treatment against COVID-19.
Even though both drugs have received approval from the Food and Drug Administration, the approvals are not for COVID-19. To be used on a widespread basis, the drugs would need approval following clinical trials.
Still, that hasn’t stopped some people from trying to acquire the potential antiviral by any means possible.
“Well it finally happened to me,” pharmacist Katherine Rowland said on Twitter. “A dentist just tried to call in scripts for hydroxychloroquine + azithromycin for himself, his wife, & another couple (friends). NOPE. I have patients with lupus that have been on [hydroxychloroquine] for YEARS and now can’t get it because it’s on backorder.”
According to the University of Utah, several doctors tried writing prescriptions for both themselves and for family friends to hoard in case they contracted the virus. The university refused to fill their prescriptions.
Because of stories like that, however, many people who need the drug for other conditions are finding themselves without.
According to The New York Times, 47-year-old Toni Grimes was told on Monday that she would have to wait until March 30 to refill her chloroquine prescription meant to treat her lupus. She said this is the first time she hasn’t been able to get her prescription refilled in the 13 years she’s been on it.
Grimes also runs a Phoenix-area Lupus Foundation support group and said another member also has yet to receive their refill, as well.
Such shortages have spurred the Lupus Foundation to release a statement, reading:
“The Foundation applauds the commitment of pharmaceutical companies that have pledged to increase production and supply of [vital] medications. We call on all manufacturers of hydroxychloroquine and chloroquine to do the same. However, increased production must not solely be done for the purpose of responding to COVID-19, but also to meet the existing needs of people with lupus.”
In fact, the scramble to obtain these drugs has grown so rapidly that four of the seven companies that make generic hydroxychloroquine are facing shortages. While the other three could have provided some cushion, they previously stopped making the drug altogether.
Because of the shortages, the Ohio Board of Pharmacy has banned the hoarding of these drugs. Now, people in Ohio can’t buy it unless they have lupus, rheumatoid arthritis, or a confirmed case of COVID-19.
People Are Dying Because They’re Self-Medicating
Ultimately, that may prove to be a beneficial move not only for people in Ohio who need these drugs but also for the people who don’t.
While not in the United States, reportedly, three people in Nigeria have all overdosed on the drug after self-medicating.
Because of that, Nigeria’s Centre for Disease Control issued a statement urgently warning people not to self-medicate, as such a move could lead to harm or even potential death.
In the U.S, an Arizona man died after reportedly ingesting chloroquine; however, instead of using the medical form of chloroquine, both this man and his wife took chloroquine that was supposed to be used to treat parasite infections for fish.
That woman is still alive, but she’s in critical care.
In an interview with NBC News, she said she and her husband—both of whom were in their 60’s—took it after watching several reports on television, including watching Trump laud the drug from the White House Press Room.
“I saw it sitting on the back shelf and thought, ‘Hey, isn’t that the stuff they’re talking about on TV?'” she said. “We were afraid of getting sick.”
Unfortunately, this couple’s goals were flawed from the start. Neither hydroxychloroquine nor chloroquine are being used as vaccines; rather, they are being investigated as potential antivirals. The difference here is that while vaccines prevent a person from getting the disease, antivirals are only meant to treat the disease after you already get it.
Chloroquine and Hydroxychloroquine in Clinical Trials
For widespread use, scientists need to prove that these drugs are not only effective against COVID-19 but also that the benefits outweigh the risks.
While this is a normal goal for any drug, scientists are playing especially close attention to these drugs as governments try to rapidly push them through clinical testing.
“Chloroquine is an extremely toxic drug with a terrible side effect profile,” Meghan May, a microbiologist at the University of New England College of Osteopathic Medicine, said in a written email to The New York Times. “Hydroxychloroquine is far safer, but its side effects are still significant. If it is not abundantly clear that it is beneficial, giving this drug to a critically ill patient feels risky.”
Those side effects include heart rhythm problems, severely low blood pressure, as well as muscle or nerve damage.
As reported in the journal Nature Medicine, researchers found evidence that hydroxychloroquine impedes the coronavirus’ ability to enter cells; however, that alone doesn’t mean it would do the same thing in a person or that a person could tolerate the doses used in the lab.
In a clinical trial conducted in February, scientists in China reported that chloroquine helped more than 100 patients at 10 hospitals. Because of that, the drug reportedly saw widespread use both there and in South Korea.
Still, this trial is also not enough to prove chloroquine’s effectiveness against COVID-19. Reportedly, with this study, the treated patients all had various degrees of the illness and were all treated with different doses for different amounts of time.
The trial also didn’t contain any control groups, which means that it’s also possible people could have just recovered on their own without the drug.
Another study from France has also captured many eager ears, including Trump’s. There, doctors gave hydroxychloroquine to 26 people who had been infected with the coronavirus.
Of those 26 people, six were also given an antibiotic called azithromycin, but before that study was completed, six other people dropped out. Of those, three people wound up in intensive care and one died. That’s not necessarily to say chloroquine killed them, because like that study from China, there was a lot of variation between each case. Some had been asymptomatic while others were symptomatic.
At the end of the trial, none of the six patients who had received both hydroxychloroquine and azithromycin had detectable levels of the virus. Meanwhile, over half who had received only hydroxychloroquine had no detectable levels, and only 12.5% of people who received neither drug had no detectable levels.
Once again, this single trial or even all three studies together are not enough to prove the effectiveness of these two drugs. National Institute of Allergy and Infectious Diseases Director Anthony Fauci has called such trials only anecdotal at the moment. In fact, clinical trials could take months.
Trump’s Calls for Chloroquine and Hydroxyquine
Scientists have been eyeing these drugs as potential treatments for most of the outbreak’s lifespan, but their names gained household usage after Trump announced last week that he was asking the FDA to cut “red tape” around their usage.
“It’s very powerful, but the nice part is that it’s been around for a long time so we know that if things don’t go as planned, it’s not going to kill anybody,” Trump said of chloroquine on Thursday.
Over the weekend, Trump continued to prop up those drugs, saying on Twitter, “HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine… Hopefully they will….be put in use IMMEDIATELY. PEOPLE ARE DYING, MOVE FAST, and GOD BLESS EVERYONE!”
Trump announced Monday that the federal government was working to obtain large quantities of chloroquine. It has already received 3 million doses from Bayer.
On Tuesday, New York state began two trials, one focusing on chloroquine and another focusing on hydroxychloroquine with the azithromycin.
See what others are saying: (The New York Times) (NBC News) (Politico)
2 Officers Shot, 127 Arrested in Louisville Following Breonna Taylor Decision
- Protests erupted across the country Wednesday night following the announcement that officers involved in the killing of Breonna Taylor would not face charges related to her death.
- One of the three officers was indicted on wanton endangerment because he blindly fired throughout her apartment, leading to some shots entering the neighbor’s apartment.
- Over 127 people were arrested in Louisville, and two police officers in the city were shot but are in stable condition. A suspect has been charged in the shooting.
- Across the country, many protests were peaceful, but others led to unrest, including some held in Denver and Buffalo where drivers rammed into protesters.
At least 127 people were arrested and two officers were shot Wednesday during protests in Louisville, Kentucky over the lack of charges filed against the officers involved in the killing of Breonna Taylor.
Protests began in the afternoon and carried on throughout the night after Kentucky Attorney General Daniel Cameron announced a grand jury’s decision. Two of the involved officers will face no charges, and one, Brett Hankison, was indicted on wanton endangerment. That charge does not directly link to Taylor’s death but was instead brought on over the fact that he blindly fired throughout her apartment, leading to shots entering her neighbor’s apartment.
Many were outraged that none of the officers would face charges related to Taylor’s killing, prompting protests across the country. In Louisville, where the case took place, the Courier Journal reports that the majority of the 127 arrests were over curfew and unlawful assembly violations. Two of those arrested were reporters for the Daily Caller.
Two officers were also shot after they responded to reports of gunfire at a busy intersection. They are both in stable condition and sustained non-life-threatening injuries. A suspect is in custody and was charged with two counts of first-degree assault of a police officer and other counts of first-degree wanton endangerment. The FBI will be aiding in the investigation into what happened.
After this shooting, Kentucky Governor Andy Beshear addressed his state and the protesters in it.
“Sadly we have seen at least one individual turn non-violent ways of expressing ourselves into the shooting of at least two law enforcement officers,” he said. “We know that the answer to violence is never violence. And we are thinking about those two officers and their families tonight. So I’m asking everybody, please, go home.”
Other political leaders also responded to the shooting. President Donald Trump said he spoke to Beshear and said the federal government was ready to step in as protests escalated. Beshear had already approved the deployment of the National Guard earlier on Wednesday. A curfew was also implemented in Louisville.
Presidential candidate Joe Biden said he was praying for the officers who were shot.
“Even amidst the profound grief & anger today’s decision generated, violence is never & can never be the answer,” he wrote.
More protests were held at cities all across the country, including Los Angeles, New York and Chicago.
Many protests remained peaceful as demonstrators marched, calling for justice and changes to the criminal justice system. In some places, however, protests led to unrest.
At least 13 people were arrested in Seattle during protests. Local reports say fires were set, explosives were thrown, property in the area was damaged, and some officers got hurt. In one incident in the city, a viral video shows a police bike riding over someone’s head. Police are aware of the video and told the Washington Post they would be referring it to the city’s Office of Police Accountability for an investigation.
In Portland, authorities declared a demonstration a riot after rocks were thrown at a precinct’s window. A protester also threw a molotov cocktail, which hit an officer, though the flames were extinguished. Officers said that multiple arrests were made.
Video footage captured in Denver showed a driver ramming through protesters. No one at the scene sustained major injuries. Police have detained someone related to this incident.
In Buffalo, another video shows a the driver of a truck barreling into protestors. Local reports say a person riding their bike was hit and has broken bones but is in stable condition. The driver of the truck is in police custody.
Responses to Lack of Charges
Before protests began, many took to social media to express their dissatisfaction. Ben Crump, who represents Taylor’s family, said the decision was “offensive to her memory.”
“It’s yet another example of no accountability for the genocide of persons of color by white police officers,” he wrote in a statement. “With all we know about Breonna Taylor’s killing, how could a fair and just system result in today’s decision?”
Sen. Bernie Sanders (I-Vt.) said it was time for a fundamental change in our criminal justice system.
“Everyone-and I do mean everyone-should be against officers being able to walk into your home and kill you with impunity,” activist Brittnay Packnett Cunningham wrote.
Celebrities also spoke out, including LeBron James, who said he was not surprised by the verdict but that his heart was still heavy.
Kerry Washington encouraged her followers to vote, and Daniel Levy told his to donate to the Louisville Community Bail Fund.
With all the ongoing public frustrations, Governor Beshear went on CNN and asked the state’s Attorney General to make information from the investigation public so that there can be transparency when it comes to how the decision was reached.
Taylor was killed in what has been described as a botched police raid in March. Three officers were sent to her apartment on a warrant because they believed her ex boyfriend had send drugs there. No drugs were found in the apartment.
While officers claim that they knocked and announced themselves, Taylor’s family, her boyfriend Kenneth Walker, who was there at the time, and her neighbors say they did not. When they entered the apartment, it was the middle of the night and Walker thought there was a break in, potentially by Taylor’s ex. He shot at the officers. The officers returned fire, killing Taylor.
The case has led to national outrage as Louisville officials have been slow to respond, investigate, and announce consequences.
See what others are saying: (Courier Journal) (Washington Post) (Associated Press)
4 UC Campuses Admitted Dozens of Wealthy and Well-Connected Students Despite Being Less Qualified, State Audit Finds
- University of California campuses admitted 64 less-qualified but well-connected students between 2013 and 2018, state auditor Elaine Howle said in a report published Tuesday.
- In the audit, Howle concluded that the UC system “has not treated applicants fairly or consistently.” In an interview with NBC News, she also said hundreds of more students could have been unfairly accepted into these four universities.
- In one example described in the audit, an applicant made the lowest possible scores on their application and was flagged as “do not recommend,” yet a donor relations admin passed on that application to a coach, noting that the applicant’s father had the capacity to donate major gifts to the school.
- Howle has now recommended that the UC Office of the President oversees admissions for at least three years and said campuses should be required to verify athletic recruits’ talents.
Audit of UC Campuses
The University of California admitted dozens of less-qualified, well-connected applicants over a six-year period, “[depriving] more qualified students of the opportunity for admission,” according to a state audit report published Tuesday.
The report details how four UC campuses — Berkeley, Los Angeles, Santa Barbara, and San Diego — admitted 64 students (and possibly more) between the 2013-2014 and 2018-2019 academic years. According to state auditor Elaine Howle, the majority of those applicants were white, and at least half came from families with average yearly incomes over $150,000.
In one example outlined in the report, a child of a major donor applied to UC Berkeley but received the lowest possible score on their application, which was marked “Do Not Recommend.” Despite this, a donor relations administrator later passed that application along to an unnamed coach while noting that the family had a “huge capacity” to donate and was “already a big supporter of Cal.”
According to the audit, the coach then identified that applicant as a qualified student athlete, even though the applicant “had played only a single year of the sport in high school and at a low level of competition.”
After accepting a spot at Berkeley, the student’s family donated several thousand dollars to the team, but as the report notes, “The applicant never competed with the team, and the coaches removed the applicant from the team after the season ended.”
In a different example laid out in the audit, a UCLA coach admitted a student as an athlete as a favor to a donor, even though that student’s application had already been marked “Denied.”
In fact, 22 of the total 64 applicants were admitted with the endorsement of athletic departments, despite not meeting the athletic qualifications.
In another example, an applicant who babysat for the colleague of the former admissions director was accepted into one of the schools.
In a letter to Governor Gavin Newsom and the California state legislature prefacing the report, Howle concluded “that the university has allowed for improper influence in admissions decisions, and it has not treated applicants fairly or consistently.”
“By admitting 64 noncompetitive applicants, the university undermined the fairness and integrity of its admissions process and deprived more qualified students of the opportunity for admission,” she added.
As part of several recommendations, Howle said the UC Office of the President should oversee admissions for at least three years to “ensure that all admissions decisions are merit‑based and conform to the university’s policies on admissions.”
That recommedation will likely be especially stressed for UC Berkeley, which dominated the report with 42 of the total cases.
Still, in an interview with NBC News, Howle said she believes the UC system’s unfair admissions practice could run even deeper.
“There’s at least another 400 or so students… that were really questionable,” she told the outlet.
Because of all those factors combined, Howle has also recommended that beginning with the current admissions cycle, campuses should be required to verify athletic recruits’ talents and review donation records for possible impropriety.
In general, Howle noted that “applicants’ chances of admission were also unfairly affected by UC Berkeley’s, UCLA’s, and UC San Diego’s failures to properly train and monitor the staff who review and rate applications.”
According to Howle, at times, admissions staff were “overly strict or overly lenient in their review of applications,” which made “applicants’ chances of admission unduly dependent on the individual staff who rated them rather than on the students’ qualifications.”
UC President Responds
UC President Michael Drake said Howle’s audit follows two internal audits that identified many of the same issues, with Drake noting that Howle’s audit will be used to improve the admissions system.
“Individuals involved in improper activities will be disciplined appropriately,” he stressed.
A spokesperson for UCLA said its athletics-related incidents happened before the school adopted additional safeguards. Both UCLA and UC Berkeley noted that they have improved their admissions policies within recent years and that their review processes are fair.
UC Santa Barbara also said it has adopted recent safeguards, including having faculty committees review an athlete’s academic and athletic history.
Still, Howle’s audit uncovered many more cases of unfair admissions than an internal UC audit released in February, which found only two instances of possible impropriety. That audit was ordered by then-UC President Janet Napolitano following the national college admissions scandal that has led to convictions for actresses such as Felicity Huffman and Lori Loughlin.
See what others are saying: (The Wall Street Journal) (NBC News) (CNN)
Celebrities, Tech Companies, and Others Draw Attention to National Voter Registration Day
- Celebrities including Taylor Swift, Katy Perry, Ryan Reynolds, John Legend, and others took to social media to encourage their fans to register to vote in recognition of National Voter Registration Day.
- Social media companies themselves have also launched their own efforts to get Americans to register.
- Facebook said Monday it has already registered 2.5 million people, but many say Facebook’s efforts do not go far enough and that people should be suspicious of its motives.
National Voter Registration Day
Thousands of businesses, election officials, celebrities, and others joined together Tuesday for National Voter Registration Day, a non-partisan campaign to register Americans to vote.
“National Voter Registration Day seeks to create broad awareness of voter registration opportunities to reach tens of thousands of voters who may not register otherwise,” the official website for National Voter Registration Day states.“Every year millions of Americans find themselves unable to vote because they miss a registration deadline, don’t update their registration, or aren’t sure how to register.”
The annual campaign has been highly successful in the past. According to the website, since the event first started in 2012, “nearly 3 million voters across all 50 states have registered to vote on National Voter Registration Day, including 1.3 million in 2018-2019 alone.”
But there is still a lot of work to be done. Nearly one in every four eligible Americans are currently not registered to vote, and as the campaign pointed out in a statement, “this year, due to COVID-19, voter registration is more important than ever.”
“Because of the closure of DMVs and halting of voter registration field programs amid the pandemic, the number of new and updated voter registrations collected across the country has fallen dramatically since March,” the statement continued.
To combat that, partners and community groups are hosting “both digital voter registration drives and safe, in-person registration events,” in addition to “working to provide accurate information to voters on how to prepare to cast a ballot, either through mail-in voting, early in-person voting, or going to the polls on Election Day.”
Celebrities Promote Campaign
Many partner organizations took to social media to promote the event Tuesday, as well as celebrities like Ryan Reynolds, Katy Perry, Kesha, John Legend, and more.
“This National Voter Registration Day, research the voting rights in your state and make a plan to vote,” Legend wrote on Twitter. “By making your voice heard at the polls, you can determine the future of our country’s criminal justice system.”
Taylor Swift, who, accordiong to vote.org, inspired 65,000 people to register to vote in in 2018, also shared the campaign and emphasized its importance in an Instagram story.
“Hey guys, it’s National Voter Registration Day today. The election is November 3rd. It’s really coming up, and I’ve put together a swipe-up of resources,” the singer said. “You can register if you’re a first-time voter, you can check your registration, you can request an absentee ballot, you can figure out the process of voting early. We need everyone, and it is more important than I can even possibly say.”
Facebook’s Voter Registration Efforts
In addition to celebrities joining in on the campaign on social media, most of the major social media platforms themselves also took part.
Earlier this week, Twitter said it would roll out its biggest push yet to get people to register on Tuesday. Facebook, for its part, already begun its efforts even before National Voter Registration Day.
On Monday, the company said in a statement that estimated it has already helped 2.5 million people register to vote this year through Facebook, Instagram, and Messenger — already more than the 2 million it registered in 2016 and 2018. With just over a month until the election, the platform seems it is well on its way to completing its goal of registering 4 million people by the election.
As part of its efforts to meet that goal and others, Facebook has implemented a number of initiatives. In August, the company launched a “voting information center” with resources about voting on Facebook and Instagram.
Last weekend, it held a poll worker recruitment drive and announced it would be giving paid time off its U.S.-based employees who want to work at the polls. Just over this past weekend, Facebook also started providing users with information about how to register to vote at the top of Facebook, Instagram, and Messenger.
The platform has also done a number of things internally to prepare for the election. Earlier this month, it announced several changes it had made to fight against voting misinformation, most notably including not running new political ads the week before the election.
While some say these moves by Facebook are commendable, many have believe they fall short. Others have even said we should be suspect of Facebook’s motives.
“Corporations are political entities, and we should not assume that platform voter registration campaigns are being done with only public good in mind and aren’t also strategic,” Jennifer Grygiel, a communications professor at Syracuse University who studies social media, told USA Today.
“Social media companies have a lot at stake right now as they face increasing regulation. Their efforts to register voters could be serving corporate goals, and we need to make sure they are not strategically registering voters in a way that could skew the election.”
Facebook and the Election
Facebook’s recent voter registration efforts also come as the company is receiving significant public pressure to do more ahead of the election.
Last week, numerous celebrities including Kim Kardashian-West, Demi Lovato, Jennifer Lawrence, and others boycotted Instagram and Facebook for 24 hours to demand the company do more to address misinformation and hate speech as part of the Stop Hate for Profit Campaign.
That campaign also led major boycotts against Facebook back in July by persuading huge companies like Mircosoft, Adidas, Ford, Coca-Cola, and more to temporarily halt their spending on the platform.
Despite all the mounting pressure, it is still unclear if Facebook will take any drastic steps.
During an interview with the Financial Times on Tuesday, Facebook’s Head of Global Affairs Nick Clegg said that the company will take serious steps to “restrict the circulation of content” on the platform if the presidential election descends into widespread chaos or violent unrest.
While Clegg did not provide any specifics, he did say the company had plans for a variety of outcomes, including civic unrest or having in-person votes counted faster than mail-in ballots.
While the country prepares for what is widely expected to be an incredibly contentious race, many worry that Facebook is not doing enough to prevent unrest, violence, and the misinformation in the lead up to Nov. 3rd.
As far as if Facebook will heed the demands that it do more before the election, that remains to be unseen.
“As well as fighting a rising tide of misinformation from both foreign and domestic operatives, experts warn that Facebook must prevent the platform from being used to foment violence,” The Times wrote.
“Mr. Clegg said Facebook was carrying out ‘proactive sweeps’ for dangerous groups and incitement, including ‘in areas where we know that their activity is likely to be more pronounced in other parts of the country.’”